About Us

CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies)

CAMARADES provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies.


Animals can be used to improve our understanding of a disease and to test the effectiveness of novel treatments. However translating findings from animal studies to humans in a clinical setting has not always been straightforward. CAMARADES has pioneered the use of preclinical systematic review and meta-analysis to investigate translational failure.


The interests of CAMARADES range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing preclinical meta-analysis methodology; through to the selection of candidate stroke drugs for clinical trial.


CAMARADES currently have five global national co-ordinating centres: University of Edinburgh (United Kingdom), University of Tasmania (Australia), Radboud University Nijmegen Medical Centre (The Netherlands), University of California San Francisco (USA) and Ottawa Hospital Research Institute (Canada).

For more information, please visit the CAMARADES website.





Centre of Clinical Brain Sciences
Chancellor's Building
Royal Infirmary Hospital
Edinburgh EH16 4SB
United Kingdom
Tel: +44 (0)131 465 9577

NC3Rs (National Centre for Replacement, Reduction and Refinement of Animals in Research)

The NC3Rs is a UK-based scientific organisation dedicated to replacing, refining and reducing the use of animals in research and testing (the 3Rs). The NC3Rs use the 3Rs to accelerate scientific discovery, support innovation and technological developments, and address societal concerns about animal research. The NC3Rs have a team of scientists who lead a variety of programmes focusing on three main areas:

- Funding research and early career development.

- Supporting commercialisation and facilitating technology partnering in the 3Rs through the open innovation programme, CRACK IT.

- Providing an evidence base for changes in policy, practice and regulation through data sharing and knowledge exchange, and dissemination through guidelines, publications, online resources and scientific events.


The NC3Rs collaborate with scientists and organisations from across the life sciences sector, nationally and internationally, including universities, the pharmaceutical, chemical and consumer products industries, other research funders, and regulatory authorities.

For more information, please visit the NC3Rs website.


Contact NC3Rs:


Gibbs Building 
215 Euston Road 
London NW1 2BE
Tel: +44 (0)20 7611 2233
Fax: +44 (0)20 7611 2260


SyRF is an NC3Rs-funded initiative by CAMARADES to support the application of evidence synthesis techniques to preclinical research. We aim to advance the 3Rs and increase the successful translation of preclinical research to clinical benefit.

We aim to provide a single, easily accessible source of educational materials, guidance and practical applications to researchers wishing to embark on systematic review and meta-analysis of data from preclinical studies.

SyRF also supports methodological development for preclinical meta-analysis and the creation of pathways to encourage best practice in preclinical research.  

We invite both new and experienced preclinical systematic review authors to engage with the multiple facets of SyRF and warmly welcome any feedback.